Title of article
Synthesis and evaluation of geldanamycin–testosterone hybrids
Author/Authors
Scott D. Kuduk، نويسنده , , Christina R. Harris، نويسنده , , Fuzhong F. Zheng، نويسنده , , Laura Sepp-Lorenzino، نويسنده , , Quathek Ouerfelli، نويسنده , , Neal Rosen، نويسنده , , Samuel J. Danishefsky، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
1303
To page
1306
Abstract
Geldanamycin (GDM) binds to the Hsp90 chaperone protein resulting in the degradation of several important signaling proteins. A series of GDM–testosterone linked hybrids has been synthesized and evaluated for activity against prostate cancer cell lines. The hybrid with the greatest activity exhibits potent and selective cytotoxicity against prostate cancer cells containing the androgen receptor.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790858
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