Title of article
synthetic conversion of acat inhibitor to acetylcholinesterase inhibitor
Author/Authors
Rika Obata، نويسنده , , Toshiaki Sunazuka، نويسنده , , Kazuhiko Otoguro، نويسنده , , Hiroshi Tomoda، نويسنده , , Yoshihiro Harigaya، نويسنده , , Satoshi mura، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
2
From page
1315
To page
1316
Abstract
Natural product acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor pyripyropene A was synthetically converted to acetylcholinesterase (AChE) inhibitor via heterolitic cleavage of the 2-pyrone ring, followed by γ-acylation/cyclization with several aroyl chlorides. The 4-pyridyl analogue selectively showed AChE inhibitory activity (IC50=7.9 μM) and no ACAT inhibitory activity IC50=>1000 μM.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790861
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