Title of article
Synthesis and bioactivities of novel piperidylpyrimidine derivatives: inhibitors of tumor necrosis factor-alpha production
Author/Authors
Norio Fujiwara، نويسنده , , Hitoshi Fujita، نويسنده , , Kiyotaka Iwai، نويسنده , , Ayumu Kurimoto، نويسنده , , Shinobu Murata، نويسنده , , Hajime Kawakami، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
1317
To page
1320
Abstract
New piperidylpyrimidine derivatives, including quinazolines, were prepared, and their abilities to inhibit TNF-α production evaluated. Some compounds showed potent inhibitory activity in mouse macrophages stimulated with LPS. The synthesis and structure–activity relationships of these compounds are described.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790862
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