Title of article
Synthesis of tetrakis(multifluoro-4-pyridyl)porphin derivatives as acetylcholinesterase inhibitors
Author/Authors
Sin Chul Moon، نويسنده , , Jung-Hyu Shin، نويسنده , , Bong Ho Jeong، نويسنده , , Hee Seok Kim، نويسنده , , Byung Soo Yu، نويسنده , , Ji Sook Lee، نويسنده , , Bang Sook Lee، نويسنده , , Sung Keon Namgoong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
1435
To page
1438
Abstract
New tetrakis(multifluoro-4-pyridyl)porphin derivatives (2–4) and water soluble porphyrin (5) were synthesized to investigate their interactions with acetylcholinesterase from electric eel. These compounds have been found to be the potent reversible inhibitors of the enzyme with Ki values of μM range. In addition, porphyrin (5) showed broad spectrum of anticancer activities.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790890
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