Title of article
Mechanistic studies on prolyl-4-hydroxylase: the vitamin c requiring uncoupled oxidation
Author/Authors
Min Wu، نويسنده , , Hong-sik Moon، نويسنده , , Asta Pirskanen and، نويسنده , , Johanna Myllyharju، نويسنده , , Kari I. Kivirikko، نويسنده , , Tadhg P. Begley and Steven E. Ealick، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
1511
To page
1514
Abstract
A deuteriated substrate for the human type I prolyl-4-hydroxylase was synthesized and its V/K deuterium isotope effect was determined to be 3.4 ± 0.2. This isotope effect was attributed to the uncoupled oxidation. A dehydroproline containing tetrapeptide was also found to stimulate the uncoupled oxidation.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790909
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