Title of article
The design and synthesis of thrombin inhibitors: analogues of MD805 containing non-polar surrogates for arginine at the P1 position
Author/Authors
Urs Baettig، نويسنده , , Lyndon Brown، نويسنده , , Derek Brundish، نويسنده , , Colin Dell، نويسنده , , Alex Furzer، نويسنده , , Sheila Garman، نويسنده , , Diana Janus، نويسنده , , Peter D. Kane، نويسنده , , Garrick Smith، نويسنده , , Clive V. Walker، نويسنده , , Xiaoling Cockcroft، نويسنده , , John Ambler، نويسنده , , Andrew Mitchelson، نويسنده , , Mark D. Talbot، نويسنده , , Morris Tweed، نويسنده , , Nicholas Wills، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
1563
To page
1566
Abstract
A series of monocyclic and bicyclic amino acids have been synthesised and incorporated into thrombin inhibitors based on CGH728, an analogue of the Mitsubishi compound MD805. Benzthiazolylalanine (Bta) was found to be a good non-polar substitute for arginine at the P1 position, yielding compounds with low nanomolar potency and good selectivity for thrombin.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790922
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