Title of article
Naphthalene carboxamides as inhibitors of human cytomegalovirus DNA polymerase
Author/Authors
Valerie A. Vaillancourt، نويسنده , , Michele M. Cudahy، نويسنده , , Sandra A. Staley، نويسنده , , Roger J. Brideau، نويسنده , , Steven J. Conrad، نويسنده , , Mary L. Knechtel، نويسنده , , Nancee L. Oien، نويسنده , , Janet L. Wieber، نويسنده , , Yoshihiko Yagi، نويسنده , , Michael W. Wathen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
2079
To page
2081
Abstract
ortho-Hydroxynaphthalene carboxamides have been identified as inhibitors of HCMV DNA polymerase. SAR investigations have demonstrated that both the amide and hydroxy functionalities are required for activity. Substitution on the naphthalene ring has led to inhibitors with submicromolar IC50s against HCMV polymerase. These compounds have been found to be >100-fold selective for inhibition of HCMV polymerase versus human alpha polymerase and display antiviral activity in a cell-based plaque reduction assay.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791044
Link To Document