Title of article
Identification of optimal anion spacing for anti-HIV activity in a series of cosalane tetracarboxylates
Author/Authors
Gitendra C. Paul، نويسنده , , Erik De Clercq، نويسنده , , Christophe Pannecouque، نويسنده , , Myriam Witvrouw، نويسنده , , Tracy L. Loftus، نويسنده , , Jim A. Turpin، نويسنده , , Robert W. BuckheitJr.، نويسنده , , Mark Cushman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
2149
To page
2152
Abstract
The binding of the anti-HIV agent cosalane to CD4 is thought to involve ionic interactions of negatively charged carboxylates of the ligand with positively charged residues on the surface of the protein. An investigation of the optimal anion distances for anti-HIV activity in a series of cosalane tetracarboxylate analogues has been completed, and maximal activity results when the two proximal and the two distal carboxylates are separated by eight atoms.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791060
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