Title of article
Diphenylsulfone muscarinic antagonists: piperidine derivatives with high m2 selectivity and improved potency
Author/Authors
William Billard، نويسنده , , Herbert BinchIII، نويسنده , , Kristen Bratzler، نويسنده , , Lian-Yong Chen، نويسنده , , Gordon CrosbyJr.، نويسنده , , Ruth A. Duffy، نويسنده , , Sundeep Dugar، نويسنده , , Jean Lachowicz، نويسنده , , Robert McQuade، نويسنده , , Pradeep Pushpavanam، نويسنده , , Vilma B. Ruperto، نويسنده , , Lisa A. Taylor، نويسنده , , John W. Clader، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
2209
To page
2212
Abstract
Piperidine analogues of our previously described piperazine muscarinic antagonists are described. Piperidine analogues show a distinct structure–activity relationship (SAR) that differs from comparable piperazines. Compounds with high selectivity and improved potency for the M2 receptor have been identified. The lead compound, 12b, increases acetylcholine release in vivo. Compounds of this class may be useful for the treatment of cognitive disorders such as Alzheimerʹs disease (AD).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791074
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