Title of article
The synthesis and biological evaluation of a novel series of phthalazine PDE4 inhibitors I
Author/Authors
Mauro Napoletano، نويسنده , , Gabriele Norcini، نويسنده , , Franco Pellacini، نويسنده , , Francesco Marchini، نويسنده , , Gabriele Morazzoni، نويسنده , , Pierpaolo Ferlenga، نويسنده , , Lorenzo Pradella، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
2235
To page
2238
Abstract
This communication describes the synthesis and in vitro evaluation of a novel and potent series of phosphodiesterase type IV (PDE4) inhibitors. The compounds described represent conformationally constrained analogues of RP 73401, Piclamilast. Preliminary evidences of reduced side effects of 11 compared to standards are also reported.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791079
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