Title of article
The design and synthesis of novel NK1/NK2 dual antagonists
Author/Authors
Gregory A. Reichard، نويسنده , , Zachary T. Ball، نويسنده , , Robert Aslanian، نويسنده , , John C. Anthes، نويسنده , , Neng-Yang Shih، نويسنده , , John J. Piwinski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
2329
To page
2332
Abstract
Functional probing of the backbone of the Sanofi NK2 antagonist SR 48968 has resulted in the discovery of two new classes of NK1/NK2 dual antagonists: the diamine class and the oxime class. The addition of the amino or the oxime functional group results in the reversal of the stereochemical preference of the NK2 receptor.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791101
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