Title of article
1,2-disubstituted indole, azaindole and benzimidazole derivatives possessing amine moiety: a novel series of thrombin inhibitors
Author/Authors
Kumiko Takeuchi، نويسنده , , Jolie A. Bastian، نويسنده , , Donetta S. Gifford-Moore، نويسنده , , Richard W. Harper، نويسنده , , Shawn C. Miller، نويسنده , , Jeffrey T. Mullaney، نويسنده , , Daniel J. Sall، نويسنده , , Gerald F. Smith، نويسنده , , Minsheng Zhang، نويسنده , , Matthew J. Fisher، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
5
From page
2347
To page
2351
Abstract
A novel series of 1,2-disubstituted indole, azaindole and benzimidazole derivatives possessing an amine moiety was identified as thrombin inhibitors. An indole with basic diamine moieties (12a) was the most potent thrombin inhibitor in the series with Kass=197 × 106 L/mol.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791105
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