Title of article
Stereoselective binding of an enantiomeric pair of stromelysin-1 inhibitors caused by conformational entropy factors
Author/Authors
Matthew H. Parker، نويسنده , , Daniel F. Ortwine، نويسنده , , Patrick M. OʹBrien، نويسنده , , Elizabeth A. Lunney، نويسنده , , Craig A. Banotai، نويسنده , , William T. Mueller، نويسنده , , PatrickMcConnell، نويسنده , , Christie G. Brouillette، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
2427
To page
2430
Abstract
Isothermal titration calorimetry was used to analyze the binding of an enantiomeric pair of inhibitors to the stromelysin-1 catalytic domain. Differences in binding affinity are attributable to different conformational entropy penalties suffered upon binding. Two possible explanations for these differences are proposed.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791122
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