Title of article
Multistep solution-Phase parallel synthesis of spiperone analogues
Author/Authors
Henrik C. Hansen، نويسنده , , Roger Olsson، نويسنده , , Glenn Croston، نويسنده , , Carl-Magnus Andersson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
5
From page
2435
To page
2439
Abstract
A flexible, multistep parallel synthesis of spiperone analogues is described. A library of 4-substituted piperidines, assembled utilizing reductive amination and acylation protocols, was alkylated either homogeneously or heterogeneously, exploiting a product release only concept, to afford an oxa-series of spiperone analogues. Screening of the products at 5-HT2 and D2 receptors revealed 5-HT2A antagonists with improved selectivity compared to spiperone and AMI-193
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791124
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