Title of article
In vitro selection of hematoporphyrin binding DNA aptamers
Author/Authors
Atsushi Okazawa، نويسنده , , Hiroshi Maeda، نويسنده , , Eiichiro Fukusaki، نويسنده , , Yoshio Katakura، نويسنده , , Akio Kobayashi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
2653
To page
2656
Abstract
DNA aptamers that bind to hematoporphyrin IX (HPIX) were isolated using an in vitro selection technique. Most aptamers obtained after the 7th and 10th rounds contained guanine-rich sequences. Binding assay using fluorescence polarization technique and structural analysis by CD spectra revealed that the parallel guanine-quartet structure of the aptamer participates in the recognition of HPIX.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791174
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