Title of article
2-Aryl tryptamines: selective high-affinity antagonists for the h5-HT2A receptor
Author/Authors
Graeme I. Stevenson، نويسنده , , Adrian L. Smith، نويسنده , , Stephen Lewis، نويسنده , , Stephen G. Michie، نويسنده , , Joseph G. Neduvelil، نويسنده , , Smita Patel، نويسنده , , Rosemarie Marwood، نويسنده , , Shil Patel، نويسنده , , José L. Castro، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
2697
To page
2699
Abstract
A series of 2-aryl tryptamines have been identified as high-affinity h5-HT2A antagonists. Structure–activity relationship studies have shown that h5-HT2A affinity can be attained via modifications to the tryptamine side chain and that selectivity over h5-HT2C and hD2 receptors can be controlled by suitable C-2 aryl groups.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791185
Link To Document