Title of article
Benzylidene ketal derivatives as M2 muscarinic receptor antagonists
Author/Authors
Craig D. Boyle، نويسنده , , Samuel Chackalamannil، نويسنده , , Lian-Yong Chen، نويسنده , , Sundeep Dugar، نويسنده , , Pradeep Pushpavanam، نويسنده , , William Billard، نويسنده , , Herbert BinchIII، نويسنده , , Gordon Crosby، نويسنده , , Mary Cohen-Williams، نويسنده , , Vicki L. Coffin، نويسنده , , Ruth A. Duffy، نويسنده , , Vilma Ruperto، نويسنده , , Jean E. Lachowicz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
2727
To page
2730
Abstract
Benzylidene ketal derivatives were investigated as selective M2 receptor antagonists for the treatment of Alzheimerʹs disease. Compound 10 was discovered to have subnanomolar M2 receptor affinity and 100-fold selectivity against other muscarinic receptors. Also, 10 demonstrated in vivo efficacy in rodent models of muscarinic activity and cognition.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791191
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