Title of article
The design of phenylglycine containing benzamidine carboxamides as potent and selective inhibitors of factor Xa
Author/Authors
Stuart D. Jones، نويسنده , , John W. Liebeschuetz، نويسنده , , Phillip J. Morgan، نويسنده , , Christopher W. Murray، نويسنده , , Andrew D. Rimmer، نويسنده , , Jonathan M. E. Roscoe، نويسنده , , Bohdan Waszkowycz، نويسنده , , Pauline M. Welsh، نويسنده , , William A. Wylie، نويسنده , , Stephen C. Young، نويسنده , , Harry Martin، نويسنده , , Jacqui Mahler، نويسنده , , Leo Brady، نويسنده , , Kay Wilkinson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
733
To page
736
Abstract
Factor Xa, a critical serine protease in the blood coagulation cascade, has become a target for inhibition as a strategy for the invention of novel anti-thrombotic agents. Here we describe the development of phenylglycine containing benzamidine carboxamides as novel, potent and selective inhibitors of factor Xa.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791262
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