Title of article
Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity
Author/Authors
Junko Ohkanda، نويسنده , , Jeffrey W. Lockman، نويسنده , , Kohei Yokoyama، نويسنده , , Michael H. Gelb، نويسنده , , Simon L. Croft، نويسنده , , Howard Kendrick، نويسنده , , Maria Isabel Harrell، نويسنده , , Jean E. Feagin، نويسنده , , Michelle A. Blaskovich، نويسنده , , Said M. Sebti، نويسنده , , Andrew D. Hamilton، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
761
To page
764
Abstract
Malaria continues to represent a very serious health problem in the tropics. The current methods of clinical treatment are showing deficiencies due to the increased incidence of resistance in the parasite. In the present paper we report the design, synthesis, and evaluation of potential antimalarial agents against a novel target, protein farnesyltransferase. We show that the most potent compounds are active against Plasmodium falciparum in vitro at submicromolar concentrations.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791269
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