Title of article
Synthesis and in vitro cytotoxicity of novel long chain busulphan analogues
Author/Authors
George Kokotos، نويسنده , , Violetta Constantinou-Kokotou، نويسنده , , José M. Padr?n، نويسنده , , Godefridus J. Peters، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
3
From page
861
To page
863
Abstract
Two novel long chain alkanediol dimethanesulphonates, analogues of busulphan, were synthesized. Their in vitro cytotoxicity was evaluated against six solid tumor cell lines (A2780, H322, LL, WiDr, C26-10 and UMSCC-22B). 2-Tetradecylbutane-1,4-diol dimethanesulphonate was proved to be the most active compound exhibiting IC50 values between 20.82 and 26.36 μM.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791293
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