Title of article
Synthesis of thiophene-2-carboxamidines containing 2-amino-thiazoles and their biological evaluation as urokinase inhibitors
Author/Authors
Kenneth J. Wilson، نويسنده , , Carl R. Illig، نويسنده , , Nalin Subasinghe، نويسنده , , James B. Hoffman، نويسنده , , M. Jonathan Rudolph، نويسنده , , Richard Soll، نويسنده , , Christopher J. Molloy، نويسنده , , Roger Bone، نويسنده , , David Green، نويسنده , , Troy Randall، نويسنده , , Marie Zhang، نويسنده , , Frank A. Lewandowski، نويسنده , , Cong-Zhao Zhou، نويسنده , , Celia Sharp، نويسنده , , Diane Maguire، نويسنده , , Bruce Grasberger، نويسنده , , Renee L. DesJarlais، نويسنده , , John Spurlino، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
915
To page
918
Abstract
The serine protease urokinase (uPa) has been implicated in the progression of both breast and prostate cancer. Utilizing structure based design, the synthesis of a series of substituted 4-[2-amino-1,3-thiazolyl]-thiophene-2-carboxamidines is described. Further optimization of this series by substitution of the terminal amine yielded urokinase inhibitors with excellent activities.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791305
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