Title of article
Synthesis and biological evaluation of benzo[b]naphthyridones, a series of new topical antibacterial agents
Author/Authors
Michel Tabart، نويسنده , , Guy Picaut، نويسنده , , Jean-François Desconclois، نويسنده , , Sylvie Dutka-Malen، نويسنده , , Yvette Huet، نويسنده , , Nadine Berthaud، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
3
From page
919
To page
921
Abstract
We describe here the synthesis and biological evaluation of a series of benzo[b]naphthyridones, a new family of tricyclic antibacterial compounds that have a Gram-positive spectrum of activity. RP60556A, one of the most potent of these compounds, is bactericidal against multiresistant cocci, especially multiresistant Staphylococcus aureus strains. Its physico-chemical and biological properties make it particularly suitable for topical antibacterial use.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791306
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