Title of article
Spirocyclic nonpeptide glycoprotein IIb–IIIa antagonists. Part 1: design of potent and specific 3,9-diazaspiro[5.5]undecanes
Author/Authors
M. S. Smyth، نويسنده , , J. Rose، نويسنده , , M. M. Mehrotra، نويسنده , , J. Heath، نويسنده , , G. Ruhter، نويسنده , , T. Schotten، نويسنده , , J. Seroogy، نويسنده , , D. Volkots، نويسنده , , A. Pandey، نويسنده , , R. M. Scarborough، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
1289
To page
1292
Abstract
The synthesis and biological activity of novel glycoprotein IIb–IIIa antagonists containing the 3,9-diazaspiro[5.5]undecane nucleus are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of the spirocyclic structures as a central template for nonpeptide RGD mimics.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791393
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