Title of article
Spirocyclic nonpeptide glycoprotein IIb–IIIa antagonists. Part 2: design of potent antagonists containing the 3-azaspiro[5.5]undec-9-yl template
Author/Authors
A. Pandey، نويسنده , , J. Seroogy، نويسنده , , D. Volkots، نويسنده , , M. S. Smyth، نويسنده , , J. Rose، نويسنده , , M. M. Mehrotra، نويسنده , , J. Heath، نويسنده , , G. Ruhter، نويسنده , , T. Schotten، نويسنده , , R. M. Scarborough، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
1293
To page
1296
Abstract
The synthesis and biological activity of novel glycoprotein IIb–IIIa anatagonists containing 3-azaspiro[5.5]undec-9-yl nucleus are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of the monoazaspirocyclic structure as central template for nonpeptide RGD mimics.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791394
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