Title of article
A New Structural Class of Selective and Non-covalent Inhibitors of the Chymotrypsin-like Activity of the 20S Proteasome
Author/Authors
C. Garc?a-Echeverr?a، نويسنده , , P. Imbach، نويسنده , , D. France، نويسنده , , P. Fürst، نويسنده , , M. Lang، نويسنده , , M. Noorani، نويسنده , , Thomas D. Scholz، نويسنده , , J. Zimmermann، نويسنده , , P. Furet، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
3
From page
1317
To page
1319
Abstract
We describe the identification and in vitro characterization of a series of 2-aminobenzylstatine derivatives that inhibit non-covalently the chymotrypsin-like activity of the 20S proteasome. Our initial SAR data demonstrate that the 2-aminobenzylstatine core structure can effectively serve as the basis for designing potent, selective and non-covalent inhibitors of the chymotrypsin-like activity of the 20S proteasome
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791399
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