Title of article
Synthesis and hydrolytic stability studies of albendazole carrier prodrugs
Author/Authors
Francisco Hern?ndez-Luis، نويسنده , , Alicia Hern?ndez-Campos، نويسنده , , Lilian Yépez-Mulia، نويسنده , , Roberto Cedillo-Rivera، نويسنده , , Rafael Castillo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
1359
To page
1362
Abstract
Three N-acyl (2, 3, and 4), two N-alkoxycarbonyl (5 and 6), and one N-acyloxymethyl (7) derivatives of albendazole (1) have been prepared and assessed as potential prodrugs. The determination of the aqueous solubility and partition coefficient, as well as the conversion of these derivatives to 1 in buffer solution, human plasma, and pig liver esterase were determined.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791409
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