Title of article
Structure–activity relationships of phenylcyclohexene and biphenyl antitubulin compounds against plant and mammalian cells
Author/Authors
David H. Young، نويسنده , , Colin M. Tice، نويسنده , , Enrique L. Michelotti، نويسنده , , Renee C. Roemmele، نويسنده , , Richard A. Slawecki، نويسنده , , Fernando M. Rubio، نويسنده , , Judith A. Rolling، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
1393
To page
1396
Abstract
Phenylcyclohexenes (PCHs) [e.g., trans-4-nitro-5-(2,3,4-trimethoxyphenyl)cyclohexene, 2d] were found to bind weakly to the colchicine site of bovine tubulin, but are the first mimics of colchicine found to have high activity towards plant cells. Structure–activity relationships for PCHs and biphenyl AC-ring analogues of colchicine (e.g., 2,3,4,4′-tetramethoxy-2′-methyl-1,1′-biphenyl, 3e) are discussed.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791417
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