• Title of article

    Biological evaluation of hepatitis c virus helicase inhibitors

  • Author/Authors

    Chee Wee Phoon، نويسنده , , Poh Yong Ng، نويسنده , , Anthony E. Ting، نويسنده , , Su Ling Yeo، نويسنده , , Mui Mui Sim، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2001
  • Pages
    4
  • From page
    1647
  • To page
    1650
  • Abstract
    A small chemical library has been synthesized and assayed for inhibition of HCV helicase activity. This study provides the structure–activity relationship of the reported inhibitors, with emphasis placed on the aminophenylbenzimidazole moiety and the linkers. Our data highlight the importance of preserving the aminophenylbenzimidazole core and the hydrophobic linkers for biological activity. The development of a robust HCV helicase assay is also described.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2001
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    791471

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=791471