Title of article
Synthesis and biological activity of novel macrocyclic antifungals: modification of the tyrosine moiety of the lipopeptidolactone FR901469
Author/Authors
J. DAVID BARRETT، نويسنده , , Akira Tanaka، نويسنده , , Keiko Harada، نويسنده , , Etsuko Watabe، نويسنده , , Katsuyuki Maki، نويسنده , , Fumiaki Ikeda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
7
From page
1843
To page
1849
Abstract
A series of tyrosine-modified derivatives of the macrocyclic lipopeptidolactone FR901469 have been prepared and evaluated for in vitro and in vivo antifungal activity and for hemolytic activity towards red blood cells. Compound 14 displayed significantly reduced hemolytic potential at 1 mg/mL and a comparable protective effect to FR901469 in a mouse candidiasis model.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791516
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