Title of article
Preparation of oligonucleotides without aldehyde abasic sites
Author/Authors
Achim H. Krotz، نويسنده , , Hans Gaus، نويسنده , , Vasulinga T. Ravikumar، نويسنده , , Douglas L. Cole، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
5
From page
1863
To page
1867
Abstract
High-quality oligonucleotides are obtained by selective modification of sequences containing aldehyde apurinic sites with a new chromatographic tag followed by RP-HPLC separation. Hydroxylamine derivative 1 of a water soluble nonionic surfactant modifies oligonucleotides selectively at abasic sites leading to significantly increased retention.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791520
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