Title of article
Cyclic imides as potent and selective α-1A adrenergic receptor antagonists
Author/Authors
Robert M. DiPardo، نويسنده , , Michael A. Patane، نويسنده , , Randall C. Newton، نويسنده , , RoseAnn Price، نويسنده , , Theodore P. Broten، نويسنده , , Raymond S. L. Chang، نويسنده , , Richard W. Ransom، نويسنده , , Jerry Di Salvo، نويسنده , , Roger M. Freidinger، نويسنده , , Mark G. Bock، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
1959
To page
1962
Abstract
We disclose a new compound class of potent and selective α-1A adrenergic receptor antagonists exemplified by the geminally, disubstituted cyclic imide 7. The optimization of lead compounds resulting in the cyclic imide motif is highlighted. The results of in vitro and in vivo studies of selected compounds are presented.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791542
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