Title of article
Discovery of Thioazepinone Ligands for Src SH2: From Non-specific to Specific Binding
Author/Authors
Dominique Lesuisse، نويسنده , , Pierre Deprez، نويسنده , , Eva Albert، نويسنده , , Tran Thien Duc، نويسنده , , Benoit Sortais، نويسنده , , Dominique Gofflo، نويسنده , , Véronique Jean-Baptiste، نويسنده , , Jean-Pierre Marquette، نويسنده , , Bernard Schoot، نويسنده , , Edoardo Sarubbi، نويسنده , , Gudrun Lange، نويسنده , , Pierre Broto، نويسنده , , Eliane Mandine، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
5
From page
2127
To page
2131
Abstract
The structure-based design and synthesis of new thioazepinones as ligands for Src SH2 protein is presented. From benzothioazepinones, ligands with somewhat unspecific binding properties, simpler thioazepinones were designed, the best ones demonstrated nanomolar affinity for Src SH2. A few of these new ligands were crystallized with the protein and demonstrated a specific binding mode with the protein.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791581
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