Title of article
Conformational search of antisense nucleotides
Author/Authors
Stefano Alcaro، نويسنده , , Andrea Tafi، نويسنده , , Francesco Ortuso، نويسنده , , Lucyna A. Wo niak، نويسنده , , Eszter Gacs-Baitz، نويسنده , , Maurizio Botta، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
5
From page
2273
To page
2277
Abstract
A preliminary MMFF implementation of selenium atom parameters necessary to model the nucleoside 1 is reported. X-ray structures of two compounds 1 and 2 have been used as references. Ab initio methods have been adopted for checking torsional energy profile and charge distribution. Monte Carlo calculations and energy minimization in solvation complete the conformational search.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791614
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