Title of article
A novel phosphotyrosine mimetic 4′-carboxymethyloxy-3′-phosphonophenylalanine (cpp): exploitation in the design of nonpeptide inhibitors of pp60Src SH2 domain
Author/Authors
Noriyuki Kawahata، نويسنده , , Michael G. Yang، نويسنده , , George P. Luke، نويسنده , , William C. Shakespeare، نويسنده , , Raji Sundaramoorthi، نويسنده , , Yihan Wang، نويسنده , , Daniel Johnson، نويسنده , , Taylor Merry، نويسنده , , Shelia Violette، نويسنده , , Wei Guan، نويسنده , , Catherine Bartlett، نويسنده , , Jeremy Smith، نويسنده , , Marcos Hatada، نويسنده , , Xiaode Lu، نويسنده , , David C. Dalgarno، نويسنده , , Charles J. Eyermann، نويسنده , , Regine S. Bohacek، نويسنده , , Tomi K. Sawyer، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
5
From page
2319
To page
2323
Abstract
The novel phosphotyrosine (pTyr) mimetic 4′-carboxymethyloxy-3′-phosphonophenylalanine (Cpp) has been designed and incorporated into a series of nonpeptide inhibitors of the SH2 domain of pp60c-Src (Src) tyrosine kinase. A 2.2 Å X-ray crystal structure of 1a bound to a mutant form of Lck SH2 domain provides insight regarding the structure–activity relationships and supports the design concept of this new pTyr mimetic.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791624
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