Title of article
Monocharged inhibitors of mast cell tryptase derived from potent and selective dibasic inhibitors
Author/Authors
Jeffrey M. Dener، نويسنده , , Vivian R. Wang، نويسنده , , Kenneth D. Rice، نويسنده , , Anthony R. Gangloff، نويسنده , , Elaine Y. -L. Kuo، نويسنده , , William S. Newcomb، نويسنده , , Daun Putnam، نويسنده , , Martin Wong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
6
From page
2325
To page
2330
Abstract
Truncation of potent and selective dibasic inhibitors afforded monocharged inhibitors of human mast-cell tryptase. Using two classes of analogues as lead structures, several monocharged derivatives were identified with Ki values ranging from 0.084 to 0.21 μM against the enzyme.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791625
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