Title of article
G-Quadruplex DNA binding by a series of carbocyanine dyes
Author/Authors
Sean M. Kerwin، نويسنده , , Daekyu Sun، نويسنده , , Jonathan T. Kern، نويسنده , , Anupama Rangan، نويسنده , , Pei Wang Thomas، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
2411
To page
2414
Abstract
We have examined a number of carbocyanine dyes for their ability to bind intramolecular G-quadruplex DNA structures (G4′-DNA) using a Taq polymerase stop assay. Of the five dyes examined, only one, N,Nʹ-diethylthiacarbocyanine iodide (DTC), was found to bind to G4′-DNA. DTC was also the only dye found to inhibit human telomerase at 50 μM concentration.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791645
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