Title of article
Identification of E2F-1/Cyclin A antagonists
Author/Authors
Sushil K. Sharma، نويسنده , , Timothy M. Ramsey، نويسنده , , Ying-Nan P. Chen، نويسنده , , Weichun Chen، نويسنده , , Mary S. Martin، نويسنده , , Kenneth Clune، نويسنده , , Michael Sabio، نويسنده , , Kenneth W. Bair، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
2449
To page
2452
Abstract
A simple method for the synthesis of a rationally designed (S,S)-[Pro-Leu]-spirolactam scaffold is described. This was expanded to a small biased library of compounds mimicking the ‘ZRXL’ motif in order to identify E2F-1/Cyclin A antagonists. The synthesized compounds were evaluated in an E2F-1/Cyclin A binding assay and moderately active analogues were identified. In addition, the critical roles of Phe, Leu, Lys, and Arg residues of the identified motif were determined.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791654
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