Title of article
The discovery of novel, potent and selective PDE5 inhibitors
Author/Authors
Yingzhi Bi، نويسنده , , Patrick Stoy، نويسنده , , Leonard Adam، نويسنده , , Bin He، نويسنده , , John Krupinski، نويسنده , , Diane Normandin، نويسنده , , Ron Pongrac، نويسنده , , Laurie Seliger، نويسنده , , Andrew Watson، نويسنده , , John E. Macor، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
2461
To page
2464
Abstract
The design and synthesis of a novel scaffold for potent and selective PDE5 inhibitors are described. Compound 3a was more potent (PDE5 IC50=0.31 nM) and selective (>10,000-fold vs PDE1 and 160-fold selective vs PDE6) PDE5 inhibitor than sildenafil.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791657
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