Title of article
Asymmetric synthesis of bb-3497—A potent peptide deformylase inhibitor
Author/Authors
Lisa M. Pratt، نويسنده , , R. Paul Beckett، نويسنده , , Stephen J. Davies، نويسنده , , Steven B. Launchbury، نويسنده , , Tim J Wess and Andrew Miller، نويسنده , , Zoe M. Spavold، نويسنده , , Richard S. Todd، نويسنده , , Mark Whittaker، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
2585
To page
2588
Abstract
By screening a library of metalloenzyme inhibitors, the N-formyl-hydroxylamine derivative BB-3497 was identified as a potent inhibitor of Escherichia coli peptide deformylase with antibacterial activity both in vitro and in vivo. The homochiral synthesis of BB-3497, involving a novel asymmetric Michael addition reaction is described.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791685
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