Title of article
Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine
Author/Authors
Kelly Chibale، نويسنده , , Hayley Haupt، نويسنده , , Howard Kendrick، نويسنده , , Vanessa Yardley، نويسنده , , Ahilan Saravanamuthu، نويسنده , , Alan H. Fairlamb، نويسنده , , Simon L. Croft، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
3
From page
2655
To page
2657
Abstract
Sulfonamide and urea derivatives of quinacrine with varying methylene spacer lengths were synthesised and tested for inhibition of trypanothione reductase (TryR) and for activity in vitro against strains of the parasitic protozoa Trypanosoma, Leishmania, and Plasmodium. These derivatives are superior inhibitors of TryR relative to quinacrine with the best compound being 40 times more potent. Urea derivatives generally displayed good in vitro activity against all parasites.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791701
Link To Document