Title of article
N,N′-Bis[4-(N-alkylamidino)phenyl]homopiperazines as anti-Pneumocystis carinii agents
Author/Authors
Tien L. Huang، نويسنده , , Bin Tao، نويسنده , , Yvonne Quarshie، نويسنده , , Sherry F. Queener، نويسنده , , Isaac O. Donkor، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
3
From page
2679
To page
2681
Abstract
The synthesis, anti-Pneumocystis carinii activity and DNA binding properties of eight new N,N′-bis[4-(N-alkylamidino)phenyl]homopiperazines are reported. Compounds 2 and 8 were the most potent and caused about 70% inhibition of Pneumocystis carinii growth in a cell culture model at 1 μM concentrations.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791707
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