Title of article
Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain
Author/Authors
William R. Roush.، نويسنده , , Jianming Cheng، نويسنده , , Beth Knapp-Reed، نويسنده , , Alejandro Alvarez-Hernandez، نويسنده , , Andrej Sali and James H. McKerrow، نويسنده , , Elizabeth Hansell، نويسنده , , Juan C. Engel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
2759
To page
2762
Abstract
A new family of potent N-alkoxyvinylsulfonamide inhibitors of cruzain have been developed. Inhibitor 13 has a second order inactivation rate constant of 6,480,000 s−1 M−1 versus cruzain, and is also highly effective against Trypanosoma cruzi trypomastigotes in a tissue culture assay.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791724
Link To Document