Title of article
A designed antagonist of the thyroid hormone receptor
Author/Authors
Hikari A. I. Yoshihara، نويسنده , , James W. Apriletti، نويسنده , , John D. Baxter، نويسنده , , Thomas S. Scanlan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
5
From page
2821
To page
2825
Abstract
We synthesized an analogue of the thyromimetic GC-1 bearing the same hydrophobic appendage as the estrogen receptor antagonist ICI-164,384. While having reduced affinity for the thyroid hormone receptors compared to GC-1, it behaves in a manner consistent with a competitive antagonist in a transactivation assay.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791738
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