Title of article
Anchoring and bola cationic amphiphiles for nucleotide delivery. effects of orientation and extension of hydrophobic regions
Author/Authors
Tomonobu Yoshimura، نويسنده , , Seiji Hasegawa، نويسنده , , Naohide Hirashima، نويسنده , , Mamoru Nakanishi، نويسنده , , Tomohiko Ohwada، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
5
From page
2897
To page
2901
Abstract
Novel cationic amphiphiles, based on lithocholic acid derivatives with two structural motifs, anchoring lipids and bola lipids, were designed and synthesized. Both bear extended hydrophobic space-filling substituents. A significant effect of the orientation and extension of hydrophobic regions around the ether linkage at the 3-position was found on the efficiency of DNA delivery.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791756
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