Title of article
3-Aryl-4-aryloyl-1-(1H-imidazol-5-yl)methylpyrrole, a novel class of farnesyltransferase inhibitors
Author/Authors
Hyunil Lee، نويسنده , , Jinho Lee، نويسنده , , Youseung Shin، نويسنده , , Wonhee Jung، نويسنده , , Jong-Hyun Kim، نويسنده , , Kiwon Park، نويسنده , , Seonggu Ro، نويسنده , , Hyun-Ho Chung، نويسنده , , Jong Sung Koh، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
3
From page
2963
To page
2965
Abstract
Design, synthesis and structure–activity relationship of a class of 3-aryl-4-aryloyl-1-(1H-imidazol-5-yl)methylpyrroles as farnesyltransferase inhibitors are described. Compound 7 inhibits farnesyltransferase with an IC50 value of 4.6 nM.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791770
Link To Document