Title of article
Cellular solid-phase binding assay and mass spectrometry for screening of α4β7 integrin antagonists
Author/Authors
Dirk Gottschling، نويسنده , , Jürgen Boer، نويسنده , , Anja Schuster، نويسنده , , Bernhard Holzmann، نويسنده , , Kay-Eberhard Gottschalk and Horst Kessler، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
2997
To page
3000
Abstract
A qualitative cellular solid-phase binding assay for screening α4β7 integrin antagonists attached via photolinker to TentaGel® Macrobeads has been developed. An activation of the integrins with Mn2+ was necessary to achieve binding to the bead bound antagonists. The identification of the resin bound compounds was done by mass spectrometry.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791778
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