Title of article
Combretoxazolones: synthesis, cytotoxicity and antitumor activity
Author/Authors
Nguyen-Hai Nam، نويسنده , , Yong Kim، نويسنده , , Young-Jae You، نويسنده , , Dong-Ho Hong، نويسنده , , Hwan-Mook Kim، نويسنده , , Byung-Zun Ahn، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
3073
To page
3076
Abstract
Two series of combretoxazolones including 3,4-diaryloxazolones (6) and 4,5-diaryloxazolones (7) were synthesized and evaluated for cytotoxicity and antitumor activity. Both series showed strong cytotoxicities against a variety of tumor cell lines. Compound 6g exhibited a significant antitumor activity in BDF1 mice bearing B16 murine melanoma cells with inhibition rates of 67 and 61% at 100 and 30 mg/kg/day, respectively.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791795
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