Title of article
Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase
Author/Authors
Cristina Chamorro، نويسنده , , Esther Lobat?n، نويسنده , , Mar?a-Cruz Bonache، نويسنده , , Erik De Clercq، نويسنده , , Jan Balzarini، نويسنده , , Sonsoles Vel?zquez، نويسنده , , Ana San-Félix، نويسنده , , Mar?a-José Camarasa، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
3085
To page
3088
Abstract
N-3-Benzyloxycarbonylmethyl- and N-3-carboxymethyl-TBDMS-substituted nucleosides were synthesized and evaluated for activity against HIV replication. It was found that the N-3-carboxymethyl-TBDMS-substituted nucleosides were specific inhibitors of HIV-1 replication. They should be considered as members of a novel and original class of NNRTIs.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2001
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791798
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