Title of article
Phthalazine PDE4 inhibitors. Part 3: The synthesis and in vitro evaluation of derivatives with a hydrogen bond acceptor
Author/Authors
Mauro Napoletano، نويسنده , , Gabriele Norcini، نويسنده , , Franco Pellacini، نويسنده , , Francesco Marchini، نويسنده , , Gabriele Morazzoni، نويسنده , , Raimondo Fattori، نويسنده , , Pierpaolo Ferlenga، نويسنده , , Lorenzo Pradella، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
5
To page
8
Abstract
This communication describes the synthesis and in vitro evaluation of a novel and potent series of phthalazine phosphodiesterase type (IV) (PDE4) inhibitors. The interaction with two distinct polar binding sites allowed us to eliminate the cyclopentyloxy substitution from rolipram-like analogues.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791875
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