Title of article
Antitumor agents. Part 212: Bucidarasins A–C, three new cytotoxic clerodane diterpenes from Bucida buceras
Author/Authors
Kenichiro Hayashi، نويسنده , , Yuka Nakanishi، نويسنده , , Kenneth F. Bastow، نويسنده , , Gordon Cragg، نويسنده , , Hiroshi Nozaki، نويسنده , , Kuo-Hsiung Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
345
To page
348
Abstract
As part of a study on antitumor agents from rainforest plants, four new clerodane diterpenes, bucidarasins A–D (1–4), were isolated from Bucida buceras. Their structures were elucidated from detailed 2D NMR analyses. Compounds 1–3 showed potent cytotoxicity against human tumor cell lines with IC50 values of 0.5–1.9 μM. The potency was retained in drug resistant lines.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791969
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